Conatumumab, Gemcitabine Hydrochloride, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer

Official Title: “A Phase I/II Study of Induction Conatumumab and Gemcitabine, Followed by Conatumumab, Capecitabine and 3-D Conformal Radiation Therapy (3D-CRT) With Subsequent Maintenance Therapy for Locally Advanced Pancreatic Cancer”

RATIONALE: Monoclonal antibodies, such as conatumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as gemcitabine hydrochloride and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy may uses high energy x-rays to kill tumor cells. Giving conatumumab together with gemcitabine hydrochloride, capecitabine, and radiation therapy may kill more tumor cells.

PURPOSE: This phase I/II trial is studying the side effects and best dose of conatumumab when given together with gemcitabine hydrochloride, capecitabine, and radiation therapy and to see how well they work in treating patients with locally advanced pancreatic cancer.

OBJECTIVES:

Primary - To evaluate the maximum tolerated dose of conatumumab up to a target dose of 10 mg/kg given concurrently with capecitabine and radiotherapy following induction therapy comprising conatumumab and gemcitabine hydrochloride in patients with locally advanced pancreatic cancer. (Phase I) - To evaluate the overall survival of patients treated with this regimen. (Phase II)

Secondary - To evaluate the safety profile in patients treated with this regimen. (Phase I and II) - To evaluate the progression-free survival of patients treated with this regimen. (Phase II) - To evaluate the primary tumor response rate in patients treated with this regimen. (Phase II) - To generate translational research hypotheses. (Phase II)

OUTLINE: This is a multicenter, phase I dose-escalation study of conatumumab, followed by a phase II study. - Induction therapy: Patients receive conatumumab IV over 30-60 minutes on days 1 and 15 and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Treatment repeats every 28 days for 2 courses. - Conatumumab and chemoradiotherapy: Beginning 14-42 days after the last course of induction therapy, patients undergo 3-dimensional radiotherapy once daily, 5 days a week, for 5½ weeks (28 treatments). Patients also receive conatumumab IV over 30-60 minutes on days 1, 15, and 29 and oral capecitabine twice daily, 5 days a week, for 5½ weeks. - Maintenance therapy: Beginning 28-56 days after completion of chemoradiotherapy, patients receive conatumumab IV over 30-60 minutes on days 1 and 15 and gemcitabine hydrochloride IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up periodically.

Intervention(s) in this Clinical Trial

• Biological: conatumumab
• Drug: capecitabine
• Drug: gemcitabine hydrochloride
• Radiation: 3-dimensional conformal radiation therapy

Primary Measures

• Dose-limiting toxicity (Phase I)
  • Safety Issue?: Yes
• Overall survival (Phase II)
  • Safety Issue?: No

Secondary Measures

• Adverse events (Phase I and II)
  • Safety Issue?: Yes
• Progression-free survival (Phase II)
  • Safety Issue?: No
• Response rate (Phase II)
  • Safety Issue?: No

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed adenocarcinoma of the pancreas
• Locally advanced disease
• With and without regional adenopathy
• Unresectable disease based on institutional standardized criteria of unresectability
• OR medically inoperable
• No distant metastatic disease, second malignancy, or peritoneal seeding

PATIENT CHARACTERISTICS:

• Zubrod performance status 0-1
• Absolute granulocyte count ≥ 1,500/mm³
• Platelet count ≥ 100,000/mm³
• Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention allowed)
• Serum creatinine ≤ 1.5 mg/dL
• ALT or AST < 3 times upper limit of normal (ULN)
• Total bilirubin < 3.0 mg/dL
• Alkaline phosphatase < 3 times ULN
• Amylase ≤ 2 times ULN
• Lipase ≤ 2 times ULN
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for ≥ 3 months after the last study drug administration (for women) or for ≥ 6 months after the last study drug administration (for men)
• Able to swallow oral medications
• No other invasive malignancy within the past 2 years, except for nonmelanomatous skin cancer or carcinoma in situ of the breast, oral cavity, or cervix
• No severe, active co-morbidity, including any of the following:
• Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within the past 30 days
• Transmural myocardial infarction within the past 3 months
• Unstable angina and/or congestive heart failure requiring hospitalization within the past 6 months
• Any other cardiac condition that, in the opinion of the treating physician, would make study treatment unreasonably hazardous for the patient
• Acute bacterial or fungal infection requiring IV antibiotics
• Uncontrolled malabsorption syndrome significantly affecting gastrointestinal function
• Any unresolved bowel or bile duct obstruction
• Major resection of the stomach or small bowel that could affect the absorption of capecitabine
• AIDS based upon current CDC definition
• HIV testing is not required for study entry
• No prior allergic reaction to capecitabine or gemcitabine hydrochloride

PRIOR CONCURRENT THERAPY:

• No prior radiotherapy to the region of the study cancer that would result in overlap of radiotherapy fields
• No prior treatment with TRAIL-receptor agonists
• No prior systemic chemotherapy for pancreatic cancer
• More than 2 years since prior chemotherapy for malignancies other than pancreatic cancer
• More than 28 days since prior major surgery (e.g., biliary or gastric bypass)
• Insertion of a vascular access device, exploratory laparotomy, or laparoscopy are not considered major surgery
• No concurrent intensity-modulated radiotherapy
• No other concurrent chemotherapy
• No other concurrent monoclonal antibody therapy
• No concurrent sorivudine, brivudine A, or cimetidine
• No concurrent participation in another clinical trial
• Concurrent oral anticoagulants (e.g., warfarin) allowed provided INR is monitored

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Investigator: Radiation Therapy Oncology Group Other

Overall Clinical Trial Officials and Contacts

Christopher H. Crane, MD Principal Investigator M.D. Anderson Cancer Center  

Information obtained from ClinicalTrials.gov on February 09, 2012

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT01017822

Study ID Number: CDR0000659527

ClinicalTrials.gov Identifier: NCT01017822

Health Authority: Unspecified

Clinical trial summary from the National Cancer Institute's PDQ® database