Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms
Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning...
Brief Summary
Official Title: “Phase 4 Memantine as Adjunctive Therapy for Schizophrenia Negative Symptoms in Patients Using Clozapine. A Randomized, Double-Blind, Placebo Controled Study”
Memantine as an add-on therapy to clozapine may improve schizophrenia negative symptoms and cognitive functioning.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
- Study Primary Completion Date: January 2008
Intervention(s) in this Clinical Trial
- Drug: memantine
- memantine 10mg twice a day
- Drug: placebo
- 1 capsule of placebo twice a day
Arms, Groups and Cohorts in this Clinical Trial
- Placebo Comparator: 1
- Clozapine plus placebo
- Active Comparator: 2
- Clozapine plus memantine
Outcome Measures for this Clinical Trial
Primary Measures
- Score in Brief Psychiatric Raring Scale
- Time Frame: baseline, 4 weeks, 8 weeks, 12 weeks
Safety Issue?: No
- Time Frame: baseline, 4 weeks, 8 weeks, 12 weeks
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Under clozapine with negative symptoms
Exclusion Criteria:
- Pregnancy
- Lactation
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 60 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Hospital de Clinicas de Porto Alegre Other
Overall Clinical Trial Officials and Contacts
Clarissa S Gama, PhD Study Director Hospital de Clinicas de Porto Alegre
Additional Information
Information obtained from ClinicalTrials.gov on February 09, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00757978
Study ID Number: 05-406
ClinicalTrials.gov Identifier: NCT00757978
Health Authority: Brazil: National Committee of Ethics in Research
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00757978
