Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can predict who will get better with treatment...
Brief Summary
Official Title: “Neurofunctional Markers of SSRI Treatment Response in PTSD”
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can predict who will get better with treatment.
- Study Type: Interventional
- Study Design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
- Study Primary Completion Date: March 2012
Intervention(s) in this Clinical Trial
- Drug: paroxetine
- Paroxetine 20-40mg po QD for 12 weeks
Arms, Groups and Cohorts in this Clinical Trial
- Other: 1
Outcome Measures for this Clinical Trial
Primary Measures
- Change in brain response measured by functional magnetic resonance imaging
- Time Frame: 12 weeks
Safety Issue?: No
- Time Frame: 12 weeks
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Veterans with clinical diagnosis of post-traumatic stress disorder from combat related to deployment to Afghanistan/Iraq (Operation Enduring Freedom/Operation Iraqi
- Freedom)
Exclusion Criteria:
- Intolerance or sensitivity to paroxetine
- Major medical or neurologic illness
- Current psychotropic medication or active psychotherapy treatment
- Other major psychiatric illness
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 21 Years
Maximum Age for this Clinical Trial: 55 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: Accepts Healthy Volunteers
Clinical Trial Investigator Information
Lead Investigator: Department of Veterans Affairs U.S. Fed
Overall Clinical Trial Officials and Contacts
K. Luan Phan, MD Principal Investigator VA Ann Arbor Healthcare System
Overall Contact: Amy Kennedy, MSW (734) 845-3035 akennedy@med.umich.edu
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00700999
Study ID Number: MHBA-002-08S
ClinicalTrials.gov Identifier: NCT00700999
Health Authority: United States: Federal Government
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00700999
