Topical Oestrogens and Antimuscarinics In The Treatment Of Detrusor Overactivity
Despite the great number of reports about the efficacy of oestrogens or antimuscarinics on OAB symptoms, so far no author has tried to investigate whether the concomitant administration of these two drugs, acting on two different pathophysiological mechanisms, could have a synergic effect reducing the rate of non-responders to treatment...
Brief Summary
Official Title: “Is There A Synergic Effect Of Topical Oestrogens When Associated To Antimuscarinics In The Treatment Of Symptomatic Detrusor Overactivity”
Despite the great number of reports about the efficacy of oestrogens or antimuscarinics on OAB symptoms, so far no author has tried to investigate whether the concomitant administration of these two drugs, acting on two different pathophysiological mechanisms, could have a synergic effect reducing the rate of non-responders to treatment.
- Study Type: Interventional
- Study Design: N/A
Intervention(s) in this Clinical Trial
- Drug: Tolterodine 4 mg
- Drug: arm 2: Tolterodine 4 mg + local oestrogens once daily for 12 weeks
Arms, Groups and Cohorts in this Clinical Trial
- Active Comparator: 1
- arm 1: Tolterodine 4 mg once daily for 12 weeks
- Experimental: 2
- arm 2: Tolterodine 4 mg + local oestrogens once daily for 12 weeks
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- All post-menopausal women with symptoms of overactive bladder and urodynamically proven pure detrusor overactivity
Exclusion Criteria:
- concomitant urodynamic stress incontinence
- documented recurrent urinary tract infections
- previous antimuscarinic treatment
- previous pelvic surgery
- concomitant systemic HRT
- history of breast or endometrial cancer
- neurological disease
- clinical contraindications to treatment with oestrogen or antimuscarinics
- patients included in other ongoing clinical trials
Gender Eligibility for this Clinical Trial: Female
Minimum Age for this Clinical Trial: N/A
Maximum Age for this Clinical Trial: N/A
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Università degli Studi dell'Insubria Other
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00648310
Study ID Number: local oestrogens 9/2003
ClinicalTrials.gov Identifier: NCT00648310
Health Authority: Italy: Ethics Committee
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00648310
