HRCT Evaluation of Airway Distensibility in Lung Transplant Recipients

Official Title: “High Resolution Computed Tomographic Evaluation of Airway Distensibility in Lung Transplant Recipients: A Pilot Study”

Lung and heart-lung recipients at the University of Texas Medical Branch who have participated in the "Assessment of Cough Reflex in Lung Transplant Recipients" study who meet the specific study inclusion/exclusion criteria will have one study visit where they will undergo lung volume measurements, followed by high resolution CT scan of the lungs within 2 hours. After the initial CT scan, patients will be given a standard dose of Atrovent, followed thirty minutes later by repeat lung volume measurements and CT scan.

Arms, Groups and Cohorts in this Clinical Trial

• : A
  • All eligible patients will undergo the same procedures

Inclusion Criteria:

• lung transplant recipients >18 years of age
• at least 12 months or greater from time of transplantation

Exclusion Criteria:

• hemodynamic instability
• hypoxemia
• pneumonia
• moderate or large pleural effusion
• clinical evidence of acute rejection

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Investigator: The University of Texas, Galveston Other

Overall Clinical Trial Officials and Contacts

Alexander G Duarte, MD Principal Investigator University of Texas  

Information obtained from ClinicalTrials.gov on February 12, 2012

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00584181

Study ID Number: 07-247

ClinicalTrials.gov Identifier: NCT00584181

Health Authority: United States: Institutional Review Board