The Effect of Rosuvastatin on Adenosine Metabolism
The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation...
Brief Summary
Official Title: “Rosuvastatin Augments Dipyridamole Induced Vasodilation by Increased Adenosine Receptor Stimulation.”
The aim of this study is to show whether rosuvastatin influences adenosine metabolism.
Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
- Study Primary Completion Date: March 2008
Intervention(s) in this Clinical Trial
- Drug: placebo
- 1 dd for 7-10 days
- Drug: rosuvastatin
- 1 dd 20 mg for 7-10 days
Arms, Groups and Cohorts in this Clinical Trial
- Placebo Comparator: 1
- Experimental: 2
Outcome Measures for this Clinical Trial
Primary Measures
- forearm vasodilatory response to dipyridamole
- Time Frame: 7 days
- Time Frame: 7 days
Secondary Measures
- lipid profile
- Time Frame: 7-10 days
- Time Frame: 7-10 days
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- age 18 - 50 years
- Signed informed consent
Exclusion Criteria:
- hypertension
- hypercholesterolemia
- diabetes Mellitus
- alanine aminotransferase > 90 U/L
- creatinine Kinase > 440 U/L
- cardiovascular disease
- GFR < 80 ml/min
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 50 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: Accepts Healthy Volunteers
Clinical Trial Investigator Information
Lead Investigator: Radboud University Other
Overall Clinical Trial Officials and Contacts
Gerard Rongen, MD, PhD Study Director Radboud University Medical Centre Dep. Pharmacology-Toxicology
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00554138
Study ID Number: Rosudip01
ClinicalTrials.gov Identifier: NCT00554138
Health Authority: Netherlands: Medical Ethics Review Committee (METC)
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00554138
