Differential Metabolic Effects of Statins
The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients...
Brief Summary
The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
- Study Type: Observational
- Study Design: Observational Model: Case Control, Time Perspective: Prospective
Intervention(s) in this Clinical Trial
- Drug: statins (simvastatin, pravastatin)
Outcome Measures for this Clinical Trial
Primary Measures
- Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Low-density lipoprotein cholesterol levels > 130
Exclusion Criteria:
- Overt liver disease,
- Chronic renal failure
- Hypothyroidism
- Myopathy
- Uncontrolled diabetes
- Severe hypertension
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 25 Years
Maximum Age for this Clinical Trial: 75 Years
Clinical Trial Investigator Information
Lead Investigator: Gachon University Gil Medical Center Other
Overall Clinical Trial Officials and Contacts
Kwang K Koh, MD,PhD Principal Investigator Gachon University Gil Medical Center
Related Publications
Citations Reporting Results
Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):1205-13.
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00546559
Study ID Number: GMC-200406
ClinicalTrials.gov Identifier: NCT00546559
Health Authority: South Korea: Institutional Review Board
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00546559
