The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in human studies evaluating the effect of doxycycline therapy on aortic wall MMP-9 suggest...
Brief Summary
Official Title: “The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm”
The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in human studies evaluating the effect of doxycycline therapy on aortic wall MMP-9 suggest that the effects of doxycycline extend beyond MMP-9 inhibition, and that the effect may be dose dependent.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science
Detailed Clinical Trial Description
In this clinical trial, we evaluated the effect of two weeks of low (50 mg/day), medium (100 mg/day) or high dose (300 mg/day) doxycycline versus no medication in patients undergoing elective AAA repair. The effect of doxycycline treatment on MMP and cysteine proteases, and their respective inhibitors was evaluated in an integrative approach.
Intervention(s) in this Clinical Trial
- Drug: doxycycline
- 2 weeks once daily
Arms, Groups and Cohorts in this Clinical Trial
- No Intervention: 1
- Active Comparator: 2
- doxycycline 50 mg/day
- Active Comparator: 3
- doxycycline 100 mg
- Active Comparator: 4
- doxycycline 300 mg
Outcome Measures for this Clinical Trial
Primary Measures
- Collagenase mRNA and protein expression
- Time Frame: 2 weeks
- Time Frame: 2 weeks
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Elective open aneurysm repair
Exclusion Criteria:
- Severe kidney and liver dysfunction
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: N/A
Maximum Age for this Clinical Trial: N/A
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Leiden University Medical Center Other
Overall Clinical Trial Officials and Contacts
Jan HN Lindeman, MD, PhD Principal Investigator Leiden University Medical Center
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00538967
Study ID Number: P00.146
ClinicalTrials.gov Identifier: NCT00538967
Health Authority: Netherlands: Medical Ethics Review Committee (METC)
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00538967
