Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure
The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity. Both could influence exercise capacity in normoxic as well as hypoxic conditions...
Brief Summary
Official Title: “Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function”
The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.
Both could influence exercise capacity in normoxic as well as hypoxic conditions.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Intervention(s) in this Clinical Trial
- Drug: carvedilol
- Drug: bisoprolol
- Drug: Nebivolol
Arms, Groups and Cohorts in this Clinical Trial
- Active Comparator: Carvedilol
- Active Comparator: Bisoprolol
- Active Comparator: Nebivolol
Outcome Measures for this Clinical Trial
Primary Measures
- exercise capacity
- Time Frame: two months
- Time Frame: two months
Secondary Measures
- lung diffusion
- Time Frame: two months
- Time Frame: two months
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Chronic heart failure patients in stable clinical condition
Exclusion Criteria:
- No comorbidity
- NYHA class IV
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 80 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Centro Cardiologico Monzino Other
Overall Clinical Trial Officials and Contacts
Piergiuseppe Agostoni, MD, PhD Principal Investigator Centro Cardiologico Monzino
Related Publications
References
Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6.
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00517725
Study ID Number: R76-CCM S78/407
ClinicalTrials.gov Identifier: NCT00517725
Health Authority: Italy: Ministry of Health
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00517725
