Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect...
Brief Summary
Official Title: “Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients”
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Intervention(s) in this Clinical Trial
- Drug: allopurinol
Outcome Measures for this Clinical Trial
Primary Measures
- diastolic function uric acid levels BNP
- Time Frame: three months
- Time Frame: three months
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- chronic heart failure;
- left ventricular systolic dysfunction (ejection fraction <45%)
- stable clinical conditions in the previous three months
- optimal medical therapy for CHF
- normal sinus rhythm
- written informed consent
- age >18 years
Exclusion Criteria:
- renal failure (s-creatinine >2.5 mg/dl)
- already on allopurinol
- malignancies
- chronic inflammatory diseases
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: N/A
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Universita di Verona Other
Overall Clinical Trial Officials and Contacts
Mariantonietta Cicoira, MD, PhD Principal Investigator Division of Cardiology, University of Verona, Italy
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00477789
Study ID Number: 802
ClinicalTrials.gov Identifier: NCT00477789
Health Authority: Italy: Ethics Committee
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00477789
