Preoperative NSAID to Colorectal Cancer Patients
The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer...
Brief Summary
Official Title: “Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions”
The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Detailed Clinical Trial Description
Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.
Intervention(s) in this Clinical Trial
- Drug: Indomethacin, celecoxib, esomeprazole
Outcome Measures for this Clinical Trial
Primary Measures
- Immune reactivity
- Time Frame: Acute evaluations
- Time Frame: Acute evaluations
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Colon carcinoma scheduled for curative operation
Exclusion Criteria:
- Diabetes, steroid medication, liver and kidney impairment
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 40 Years
Maximum Age for this Clinical Trial: 80 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Göteborg University Other
Overall Clinical Trial Officials and Contacts
Kent Lundholm, MD, prof Principal Investigator Göteborg University
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00473980
Study ID Number: kl4501122
ClinicalTrials.gov Identifier: NCT00473980
Health Authority: Sweden: The National Board of Health and Welfare
Clinical Trials content is provided directly by the U.S. National Institutes of Health via ClinicalTrials.gov and is not reviewed separately by ClinicalTrialsFeeds.org. Every page of specific clinical trials information contains a unique identifier which can be used to find further details directly from the National Institutes of Health.
The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00473980
