Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma
Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease...
Brief Summary
Official Title: “Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma”
Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Detailed Clinical Trial Description
This is a double-blind, placebo-controlled crossover study of adult asthmatics given minocycline 150 mg po BID or placebo as add-on therapy for eight weeks each. Each eight week arm is separated by a four week wash-out. Spirometry is performed at the baseline and end of each arm. Daily symptoms scores, peak flow rates, and oral steroid requirements are recorded. A standardized asthma quality of life symptoms assessment is made every four weeks (AQLQ, Juniper).
Intervention(s) in this Clinical Trial
- Drug: minocycline
Outcome Measures for this Clinical Trial
Primary Measures
- Decrease in oral steroid therapy requirements.
Secondary Measures
- improvement in symptoms scores
- improvement in spirometric outcomes
- improvement in morning and evening peak flow
- decrease in rescue inhaler usage
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Adult asthmatics
- History of or current use of oral steroids to control symptoms
Exclusion Criteria:
- Pregnant women
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 75 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: State University of New York - Downstate Medical Center Other
Overall Clinical Trial Officials and Contacts
Rauno Joks, MD Principal Investigator State University of New York - Downstate Medical Center
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00456677
Study ID Number: Heikki31
ClinicalTrials.gov Identifier: NCT00456677
Health Authority: United States: Institutional Review Board
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00456677
