Radiofrequency Catheter Ablation for Chronic Atrial Fibrillation

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The purpose of this study is to determine the long-term efficacy of radiofrequency catheter ablation in patients with chronic atrial fibrillation...

Brief Summary

Official Title: “Randomized Comparison of Radiofrequency Catheter Ablation Vs. Antiarrhythmic Therapy With Amiodarone for Maintaining Sinus Rhythm in Patients With Chronic Atrial Fibrillation”

The purpose of this study is to determine the long-term efficacy of radiofrequency catheter ablation in patients with chronic atrial fibrillation.

  • Study Type: Interventional
  • Study Design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Intervention(s) in this Clinical Trial

  • Procedure: Radiofrequency catheter ablation
  • Drug: Amiodarone and cardioversion

Outcome Measures for this Clinical Trial

Primary Measures

  • Freedom from atrial fibrillation and atrial flutter in the absence of antiarrhythmic drug therapy at 1 year.

Secondary Measures

  • incidence of complications
  • changes in left atrial diameter
  • changes in left ventricular ejection fraction
  • changes in symptom severity

Criteria for Participation in this Clinical Trial

Inclusion Criteria:

  • Chronic atrial fibrillation

Exclusion Criteria:

  • Left atrial diameter >55 mm
  • Left ventricular ejection fraction <0.30
  • Contraindication to amiodarone therapy or anticoagulation with warfarin
  • Presence of a mechanical prosthetic valve
  • History of a cerebrovascular accident
  • Presence of left atrial thrombus on TEE
  • Prior attempt at catheter or surgical ablation for atrial fibrillation

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: 70 Years

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Clinical Trial Investigator Information

Lead Investigator: University of Michigan, Section of Electrophysiology (Arrhythmia Research) Other

Overall Clinical Trial Officials and Contacts

Hakan Oral, MD Principal Investigator University of Michigan  

Additional Information

Information obtained from ClinicalTrials.gov on February 12, 2012

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00272636

Study ID Number: 2002-0480

ClinicalTrials.gov Identifier: NCT00272636

Health Authority: United States: Institutional Review Board

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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00272636