Epidemiology and Control of Mansonella Perstans Infection in Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda...
Brief Summary
Official Title: “Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda”
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available. The study aims at providing data on diagnostic, epidemiological, morbidity and treatment aspects of M. perstans infections in Uganda.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Detailed Clinical Trial Description
Overall objective: to investigate diagnostic, epidemiological and treatment aspects of M.
perstans in Uganda with relevance to control
Specific objectives:
1. To establish the pattern of diurnal periodicity of M. perstans microfilaraemia in humans
2. To establish the patterns of M. perstans microfilaraemia and possible clinical manifestations related to this infection in two communities with medium to high endemicity
3. To determine the efficacy of ivermectin alone and the combination of ivermectin and albendazole on M. perstans microfilaraemia.
Intervention(s) in this Clinical Trial
- Drug: ivermectin and albendazole
Outcome Measures for this Clinical Trial
Primary Measures
- microfilariae periodicity patterns
- epidemiology of M. perstans at community level
- clinical spectre among infected
- reduction in microfilaraemia
Secondary Measures
- treatment effect on clinical manifestations
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Individuals >= 5 years with or without M. perstans infection
Exclusion Criteria:
- Individuals < 5 years
- Pregnant women
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 5 Years
Maximum Age for this Clinical Trial: N/A
Are Healthy Volunteers Accepted for this Clinical Trial?: Accepts Healthy Volunteers
Clinical Trial Investigator Information
Lead Investigator: DBL -Institute for Health Research and Development Other
Overall Clinical Trial Officials and Contacts
Asanta M Asio, Msc Principal Investigator Vector control Division, Kampala, Uganda
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00215280
Study ID Number: MV917090205
ClinicalTrials.gov Identifier: NCT00215280
Health Authority: Uganda: National Council for Science and Technology
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00215280
