The Association of Endothelial Dysfunction and Cardiac Allograft Vasculopathy

Progressive cardiac allograft vasculopathy (CAV) is a serious complication in long-term survivors after heart transplantation. Therefore, we hypothesize that CAV is a diffuse and progressive process, and endothelial function may play an important role in predicting clinical outcome after heart transplantation. Therefore, this single-blinded study is designed to evaluate endothelial function, microvascular flow response and morphology of coronary artery in cardiac allografts,

1. The simultaneous use of IVUS and Doppler wire instrumentation in different pharmacological stress;

2. Tl-201 SPECT (dipyridamole stress/rest); to evaluate the correlation of endothelial function, coronary morphology change and Tl-201 dipyridamole stress myocardial perfusion image.

Inclusion Criteria:

• 1. Heart transplant receipients who undergoing the coronary angiographic follow-up as standard protocols.

Exclusion Criteria:

• 1. Acute illness conditions including infection, congestive heart failure (NYHA Fc III, IV), etc.
• 2. Coronary angiographic finding: coronary stenosis＞30% (as grade III, IV by Klauss V et al, Am J Cardiol 1995; 76:463-6).
• 3. Creatinine >3.0 mg/dl

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 20 Years

Maximum Age for this Clinical Trial: 80 Years

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Investigator: National Taiwan University Hospital Other

Overall Clinical Trial Officials and Contacts

Chii-Ming Lee, MD, phD Principal Investigator National Taiwan University Hospital  

Overall Contact: Chii-Ming Lee, MD, phD 886-2-23123456 cmlee@ha.mc.ntu.tw

Information obtained from ClinicalTrials.gov on February 12, 2012

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00173914

Study ID Number: 9200000478

ClinicalTrials.gov Identifier: NCT00173914

Health Authority: Taiwan: Department of Health