The Renin-Angiotensin System in Essential Hypertension
Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension...
Brief Summary
Official Title: “The Renin-Angiotensin System in Essential Hypertension”
Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label
Intervention(s) in this Clinical Trial
- Drug: Enalapril 20 mg bd
- Drug: Candesartan 8 mg bd
Outcome Measures for this Clinical Trial
Primary Measures
- Change in BP
- Change in PRA and aldosterone
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Essential Hypertension
- SBP 140-159 mmHg
- DBP 90-99 mmHg
Exclusion Criteria:
- Intolerance of or allergy to ACE Inhibitors or ARBS
- Pregnant or Breastfeeding
- Pre-menopausal women
- Uncontrolled cardiac or renal failure
- Diabetes mellitus
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 70 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: St George's, University of London Other
Overall Clinical Trial Officials and Contacts
Timothy WR Doulton, BSc MRCP Principal Investigator SGUL
Overall Contact: Timothy WR Doulton, BSc MRCP +44 208 725 3176 tdoulton@sgul.ac.uk
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00141583
Study ID Number: LREC 01.87.10
ClinicalTrials.gov Identifier: NCT00141583
Health Authority: United Kingdom: Research Ethics Committee
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00141583
