Cytochrome P450 2E1 and Iron Overload
The aim of the study is to determine, in patients presenting with insulin resistance and hepatic iron overload, the effects of venesection therapy on cytochrome P450 2E1 activity by comparing the rates of metabolization of chlorzoxazone before and after venesection...
Brief Summary
Official Title: “Cytochrome P450 2E1 and Iron Overload”
The aim of the study is to determine, in patients presenting with insulin resistance and hepatic iron overload, the effects of venesection therapy on cytochrome P450 2E1 activity by comparing the rates of metabolization of chlorzoxazone before and after venesection.
- Study Type: Interventional
- Study Design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Intervention(s) in this Clinical Trial
- Procedure: venesection therapy
Outcome Measures for this Clinical Trial
Primary Measures
- chlorzoxazone metabolization rate before and after venesection
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Male patients aged from 18 to 70 years
- Hepatic iron overload measured by magnetic resonance imaging [MRI] (> 36 µmol/g)
- Related to insulin resistance
Exclusion Criteria:
- Excess alcohol consumption
- Female gender
Gender Eligibility for this Clinical Trial: Male
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 70 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Investigator Information
Lead Investigator: Rennes University Hospital Other
Overall Clinical Trial Officials and Contacts
Jean-Michel Reymann, PhD Study Chair CHU Rennes
Additional Information
Information obtained from ClinicalTrials.gov on February 12, 2012
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00138684
Study ID Number: DGS 2003/0052
ClinicalTrials.gov Identifier: NCT00138684
Health Authority: France: Afssaps - French Health Products Safety Agency
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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00138684
